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DREM Sleep Aid

product on market Capsule Systemic Formulas Bio Challenge Safety: 90/100
90/100

This product looks safe

  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 33% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Melatonin is supported by strong evidence for reducing sleep onset latency. Vitamins B5, B6, and C, along with calcium, provide general metabolic and neurological support, though their direct impact on sleep is less established. Overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Contains proprietary blend — exact ingredient amounts not disclosed

Label

Product Label

Label for DREM Sleep Aid
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Other Combinations
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calcium
9.7 mg (1% DV)
5.6 mg (56% DV)
1.1× RDA — within safe limits 2 studies — no high-quality reviews
4.5 mg (225% DV)
3.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
Vitamin C
4 mg (7% DV)
0.5 mg
Market median: 3.0mg (984 products) 240 studies (A:2, B:109)
Proprietary Blend
551 mg

Other Ingredients

Gelatin Leucine
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS FOR NUTRITIONAL USE: 1-2 capsules at bedtime or as directed. Allow 8 hours for sleeping. May require 4-5 nights to help maintain healthy sleep pattern. Then, take as needed for maintenance.

Warnings & Precautions

Keep away from Heat, Sunlight and Children.

Children and pregnant women consult a healthcare practitioner before use.

Children and pregnant women consult a healthcare practitioner before use.

Formulation Notes

Contains 0.5 mg of Melatonin.

Additional Information

Keep away from Heat, Sunlight and Children.

#427 A/13

Promotes healthy sleep and relaxation.

SOLD THROUGH PROFESSIONALS

MADE IN U.S.A.

Metadata

Product Details

UPC / SKU6 35585 04271 0
DSLD Entry Date2013-06-25
Product TypeOther Combinations
FormCapsule
BrandSystemic Formulas Bio Challenge
DSLD ID22162
Data Updated2026-04-11
Research

Research Evidence

849
Research Sources
56
Avg Quality
450
Meta Analysis
152
Rct
137
Systematic Review
73
Clinical Trial
11
Regulatory Source
7
Other
7
Guideline
3
Openfda Safety
2
Cochrane Review
2
Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023 PubMed DOI
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019 PubMed DOI
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021 PubMed DOI
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
View all evidence for Electrolytes →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.