Home/ Supplements/ Niacin/ Timed Release Niacin 500 mg

Timed Release Niacin 500 mg

product on market Tablet or Pill Major Safety: 80/100
80/100

This product is generally safe

  • Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)
  • 50% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

Niacin is used to support lipid profiles and skin health, while calcium is essential for bone density and nerve function. Research evidence for these ingredients is generally strong, though the specific evidence coverage for this formulation is limited. The profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 500mg is 14.3× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Timed Release Niacin 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Single Vitamin and Mineral
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg (3125% DV)
Exceeds UL by 14.3× (UL: 35 mg) 196 studies (A:5, B:63)
Calcium
28 mg (2% DV)

Other Ingredients

Hypromellose Stearic Acid Silica Magnesium Stearate Talc
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Directions: For adults, take one (1) tablet daily, preferably with a meal. As a reminder, discuss the supplements and medications you take with your health care providers.

Warnings & Precautions

As a reminder, discuss the supplements and medications you take with your health care providers. Warning: If you are pregnant, nursing or taking any medications, or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Notice: Use of this product may cause skin flushing, burning, itching, or rash. Do not take on an empty stomach.

Keep out of the reach of children.

Tamper resistant: Do not use if seal under cap is broken or missing.

Formulation Notes

Potency guaranteed

Free of: Yeast, wheat, gluten, milk or milk derivatives, lactose, sugar, preservatives, soy, artificial color, artificial flavor, sodium (less than 5 mg per serving).

Additional Information

Store at room temperature and avoid excessive heat.

Metadata

Product Details

UPC / SKU8 10006 70009 1
DSLD Entry Date2020-03-24
Product TypeSingle Vitamin and Mineral
FormTablet or Pill
BrandMajor
DSLD ID215904
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.