Feverfew as a preventive treatment for migraine: a systematic review

Vogler et al., 1998 | Cephalalgia | Systematic Review

Citation

Vogler B K, Pittler M H, Ernst E. Feverfew as a preventive treatment for migraine: a systematic review. Cephalalgia. 1998-Dec;18(10):704-8

Abstract

BACKGROUND: Feverfew is a popular herbal remedy advocated for the prevention of migraine. AIM: The aim of this systematic review was to look at the evidence for or against the clinical effectiveness of feverfew in migraine prevention. DATA SOURCES: Literature searches were performed using the following databases: Medline, Embase, Biosis, CISCOM, and the Cochrane Library (all from their inception to April 1998). STUDY SELECTION: Only randomized, placebo-controlled, double-blind trials were included. DATA EXTRACTION: All articles were read by two independent reviewers. Data were extracted in a predefined, standardized fashion. The methodological quality of all trials was evaluated using the Jadad score. MAIN RESULTS: Five trials met the inclusion/exclusion criteria. The majority favor feverfew over placebo. Yet important caveats exist. CONCLUSION: The clinical effectiveness of feverfew in the prevention of migraine has not been established beyond reasonable doubt.

Key Findings

Five trials met the inclusion/exclusion criteria. The majority favor feverfew over placebo. Yet important caveats exist.

Outcomes Measured

Requires manual extraction

Population

Field	Value
Population	See abstract
Sample Size	See abstract
Age Range	See abstract
Condition	See abstract

MeSH Terms

Humans
Migraine Disorders
Plant Extracts
Plants, Medicinal
Randomized Controlled Trials as Topic
Sesquiterpenes
Tanacetum parthenium

Evidence Classification

Level: Systematic Review
Publication Types: Journal Article, Systematic Review
Vertical: feverfew

Provenance

PMID: 9950629
DOI: (not available)
PMCID: Not in PMC
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09