Impact of Monacolin K-Containing Supplements on Lipid Profile: A Meta-Analysis of Randomised Controlled Trials

source extracted confidence: high 2026-04-09
#humans #randomized-controlled-trials-as-topic #dietary-supplements #lovastatin #hypercholesterolemia

Impact of Monacolin K-Containing Supplements on Lipid Profile: A Meta-Analysis of Randomised Controlled Trials

Jamialahmadi et al., 2026 | Endocrinol Diabetes Metab | Meta Analysis

Citation

Jamialahmadi Tannaz, Mirhadi Elaheh, ... Sahebkar Amirhossein. Impact of Monacolin K-Containing Supplements on Lipid Profile: A Meta-Analysis of Randomised Controlled Trials. Endocrinol Diabetes Metab. 2026-Mar;9(2):e70166. doi:10.1002/edm2.70166

Abstract

BACKGROUND: Natural products have gained attention as alternative strategies for managing dyslipidemia, particularly in individuals who are resistant or unwilling to use conventional pharmacotherapies. Monacolin K, a compound derived from natural sources, has demonstrated potential benefits in improving lipid profile indices across various doses and supplementation durations. This study aimed to quantitatively evaluate the effects of monacolin K-containing products on plasma lipid levels through a meta-analysis of clinical trials. METHODS: Data were extracted from studies that included placebo or inactive control groups, and the analysis was conducted using Comprehensive Meta-Analysis (CMA) V4 software. RESULTS: Our findings indicate that monacolin K-containing supplements are effective in lowering lipid levels, particularly low-density lipoprotein cholesterol (LDL-C). CONCLUSION: These results highlight the potential of monacolin K as a promising adjunct therapy for hypercholesterolemia management, especially for patients who have not achieved LDL-C targets with standard care or are intolerant to or unwilling to use statin therapy.

Key Findings

Our findings indicate that monacolin K-containing supplements are effective in lowering lipid levels, particularly low-density lipoprotein cholesterol (LDL-C).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Randomized Controlled Trials as Topic
  • Dietary Supplements
  • Lovastatin
  • Hypercholesterolemia
  • Lipids
  • Cholesterol, LDL
  • Anticholesteremic Agents

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Letter
  • Vertical: red-yeast-rice

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09