[Network Meta-analysis of different traditional Chinese medicine injections combined with conventional western medicine in treatment of coronary heart disease complicated with heart failure]
[Network Meta-analysis of different traditional Chinese medicine injections combined with conventional western medicine in treatment of coronary heart disease complicated with heart failure]
Zhang et al., 2025 | Zhongguo Zhong Yao Za Zhi | Other
Citation
Zhang Qi-Long, Wang Ao-Long, ... Zhu Ming-Jun. [Network Meta-analysis of different traditional Chinese medicine injections combined with conventional western medicine in treatment of coronary heart disease complicated with heart failure]. Zhongguo Zhong Yao Za Zhi. 2025-Sep;50(18):5268-5291. doi:10.19540/j.cnki.cjcmm.20250609.501
Abstract
Network Meta-analysis was performed to evaluate the efficacy and safety of different traditional Chinese medicine(TCM) injections combined with conventional western medicine in the treatment of patients with coronary heart disease complicated with heart failure. Computer searches were conducted in CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, Cochrane Library, and Web of Science databases for randomized controlled trial(RCT) of TCM injections from database establishment to December 15, 2024. Literature meeting inclusion criteria were evaluated using the Cochrane risk of bias tool, with network Meta-analysis performed by RevMan 5.4 and Stata 16 software. 237 RCTs were finally included, involving 22 730 total samples and 17 TCM injections. RESULTS:: show:(1) clinical total effective rate improvement, the top three surface under the cumulative ranking curve(SUCRA) rankings were Shuxuetong Injection + conventional western medicine, Sodium Tanshinone Ⅱ_A Sulfonate Injection + conventional western medicine, and Shuxuening Injection + conventional western medicine.(2) Left ventricular ejection fraction(LVEF) improvement, the top three SUCRA rankings were Xuesaitong Injection + conventional western medicine, Shenqi Fuzheng Injection + conventional western medicine, and Ginkgo Leaf Extract and Dipyridamole Injection + conventional western medicine.(3) Brain natriuretic peptide(BNP) reduction, the top three SUCRA rankings were Sofren Injection + conventional western medicine, Shenmai Injection + conventional western medicine, and Shuxuetong Injection + conventional western medicine.(4) N-terminal pro-brain natriuretic peptide(NT-proBNP) reduction, the top three SUCRA rankings were Shengmai Injection + conventional western medicine, Yiqi Fumai Injection + conventional western medicine, and Xinmailong Injection + conventional western medicine.(5) TCM syndrome efficacy improvement, the top three SUCRA rankings were Shenmai Injection + conventional western medicine, Xinmailong Injection + conventional western medicine, and Shenfu Injection + conventional western medicine.(6) Left ventricular end-diastolic diameter(LVEDD) reduction, the top three SUCRA rankings were Salvianolic Acids for Injection + conventional western medicine, Yiqi Fumai Injection + conventional western medicine, and Tanshinone Ⅱ_A Sodium Sulfonate Injection + conventional western medicine.(7) Cardiac output(CO) improvement, the top three SUCRA rankings were Shenqi Fuzheng Injection + conventional western medicine, Salvianolic Acids for Injection + conventional western medicine, and Shengmai Injection + conventional western medicine.(8) 6 min walk test(6MWT) improvement, the top three SUCRA rankings were Danhong Injection + conventional western medicine, Shenmai Injection + conventional western medicine, and Shenfu Injection + conventional western medicine.(9) High-sensitivity C-reactive protein(hs-CRP) reduction, the top three SUCRA rankings were Shenfu Injection + conventional western medicine, Xinmailong Injection + conventional western medicine, and Shengmai Injection + conventional western medicine. The results show that TCM injections combined with conventional western medicine can improve clinical efficacy in patients with coronary heart disease complicated with heart failure. However, given large differences in literature quality and study numbers, the above conclusions need to be verified by more high-quality clinical RCT.
Key Findings
: show:(1) clinical total effective rate improvement, the top three surface under the cumulative ranking curve(SUCRA) rankings were Shuxuetong Injection + conventional western medicine, Sodium Tanshinone Ⅱ_A Sulfonate Injection + conventional western medicine, and Shuxuening Injection + conventional western medicine.(2) Left ventricular ejection fraction(LVEF) improvement, the top three SUCRA rankings were Xuesaitong Injection + conventional western medicine, Shenqi Fuzheng Injection + conventio
Outcomes Measured
- diastolic blood pressure
- C-reactive protein
Population
| Field | Value |
|---|---|
| Population | coronary heart disease complicated |
| Sample Size | 237 |
| Age Range | See abstract |
| Condition | See abstract |
MeSH Terms
- Humans
- Drugs, Chinese Herbal
- Heart Failure
- Coronary Disease
- Randomized Controlled Trials as Topic
- Injections
- Medicine, Chinese Traditional
- Natriuretic Peptide, Brain
Evidence Classification
- Level: Other
- Publication Types: Journal Article, English Abstract, Network Meta-Analysis
- Vertical: ginkgo
Provenance
- PMID: 41507724
- DOI: 10.19540/j.cnki.cjcmm.20250609.501
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09