Consistency of Blood Pressure Response to Potassium-Enriched Salt in the China Salt Substitute Study

source extracted confidence: high 2026-04-09
#humans #male #female #blood-pressure #hypertension

Consistency of Blood Pressure Response to Potassium-Enriched Salt in the China Salt Substitute Study

Kissock et al., 2026 | Hypertension | Rct

Citation

Kissock Katrina, Neal Bruce, ... Wu Yangfeng. Consistency of Blood Pressure Response to Potassium-Enriched Salt in the China Salt Substitute Study. Hypertension. 2026-Jan;83(1):167-176. doi:10.1161/HYPERTENSIONAHA.125.24723

Abstract

BACKGROUND: Large between-person differences in blood pressure (BP) responses to sodium reduction, potassium supplementation, and potassium-enriched salt have been suggested by prior studies. However, limitations in research designs and misinterpretation of findings mean that overestimation of true between-person variation in response is likely. METHODS: Systolic BP (SBP) response during a 4-week run-in period on potassium-enriched salt was measured for 608 individuals. Participants were defined as apparently sensitive if SBP fell and apparently resistant if SBP was unchanged or rose. The effect of potassium-enriched salt compared with regular salt on SBP was then compared for apparently sensitive versus apparently resistant groups over a subsequent 12-month postrandomization period. A linear mixed model was used to determine how background within-person BP variability contributed to apparent between-person differences in BP response. RESULTS: Apparent between-person variability in SBP response during run-in was substantial (mean SBP response, -13.7 [SD, 19.3; range, -80 to +56.5] mm Hg). Run-in identified 477 individuals as apparently sensitive and 131 as apparently resistant. Mean effects on SBP of potassium-enriched salt compared with regular salt over 12 months post-randomization were -2.2 mm Hg for apparently sensitive and -7.2 mm Hg for apparently resistant individuals, with no difference between the 2 groups (P=0.068). The mixed models identified no contribution of apparent run-in sensitivity to the observed between-person differences in postrandomization BP responses to potassium-enriched salt. CONCLUSIONS: Individuals classified as responsive or resistant to potassium-enriched salt during initial exposure did not differ in their response to subsequent exposure. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00145756.

Key Findings

Apparent between-person variability in SBP response during run-in was substantial (mean SBP response, -13.7 [SD, 19.3; range, -80 to +56.5] mm Hg). Run-in identified 477 individuals as apparently sensitive and 131 as apparently resistant. Mean effects on SBP of potassium-enriched salt compared with regular salt over 12 months post-randomization were -2.2 mm Hg for apparently sensitive and -7.2 mm Hg for apparently resistant individuals, with no difference between the 2 groups (P=0.068). The mixe

Outcomes Measured

  • blood pressure
  • systolic blood pressure

Population

Field Value
Population See abstract
Sample Size 608
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Humans
  • Male
  • Female
  • Blood Pressure
  • Hypertension
  • China
  • Middle Aged
  • Potassium, Dietary
  • Sodium Chloride, Dietary
  • Adult
  • Potassium
  • Blood Pressure Determination

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: potassium-blood-pressure

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09