Effect of Magnesium Supplements on Improving Glucose Control, Blood Pressure and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A systematic review and meta-analysis
Effect of Magnesium Supplements on Improving Glucose Control, Blood Pressure and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A systematic review and meta-analysis
Maqrashi et al., 2025 | Sultan Qaboos Univ Med J | Meta Analysis
Citation
Maqrashi Nasiba Al, Busaidi Salim Al, ... Al-Maqbali Juhaina S. Effect of Magnesium Supplements on Improving Glucose Control, Blood Pressure and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A systematic review and meta-analysis. Sultan Qaboos Univ Med J. 2025-May-02;25(1):382-394. doi:10.18295/2075-0528.2848
Abstract
This study evaluated the effects of magnesium (Mg) supplementation on glycaemic control in type 2 diabetes mellitus through a meta-analysis of 23 randomised controlled trials involving 1,345 participants. Mg supplementation significantly increased serum Mg levels (weighted mean difference [WMD] = 0.69, 95% CI: 0.32 to 1.06) and reduced fasting blood glucose levels (WMD = -0.58, 95% CI: -0.87 to -0.28). However, the impact on glycated haemoglobin was minimal (WMD = -0.16, 95% CI: -0.32 to 0.00). Subgroup analysis showed a greater reduction in glycated haemoglobin among participants aged ≥65 years and those receiving longer durations of supplementation. Additionally, Mg supplementation was linked to lower diastolic blood pressure and potential improvements in lipid profile. This review highlights the importance of considering patient characteristics, dosage and intervention duration in future research on Mg supplementation for glycaemic control in diabetes.
Key Findings
This review highlights the importance of considering patient characteristics, dosage and intervention duration in future research on Mg supplementation for glycaemic control in diabetes.
Outcomes Measured
- blood pressure
- diastolic blood pressure
Population
| Field | Value |
|---|---|
| Population | See abstract |
| Sample Size | 1345 |
| Age Range | See abstract |
| Condition | blood pressure |
MeSH Terms
- Aged
- Female
- Humans
- Male
- Blood Glucose
- Blood Pressure
- Diabetes Mellitus, Type 2
- Dietary Supplements
- Glycated Hemoglobin
- Glycemic Control
- Lipids
- Magnesium
- Randomized Controlled Trials as Topic
Evidence Classification
- Level: Meta Analysis
- Publication Types: Journal Article, Meta-Analysis, Systematic Review
- Vertical: magnesium-diabetes
Provenance
- PMID: 40641714
- DOI: 10.18295/2075-0528.2848
- PMCID: PMC12244252
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09