[Network Meta-analysis of efficacy of different Chinese medicine injections in treating transient ischemic attack]

source extracted confidence: high 2026-04-09
#humans #drugs-chinese-herbal #injections #ischemic-attack-transient #randomized-controlled-trials-as-topic

[Network Meta-analysis of efficacy of different Chinese medicine injections in treating transient ischemic attack]

Han et al., 2025 | Zhongguo Zhong Yao Za Zhi | Other

Citation

Han Jin, Sun Yong-Kang, ... Wang Xin-Zhi. [Network Meta-analysis of efficacy of different Chinese medicine injections in treating transient ischemic attack]. Zhongguo Zhong Yao Za Zhi. 2025-Apr;50(8):2282-2297. doi:10.19540/j.cnki.cjcmm.20250103.501

Abstract

This study aims to evaluate the efficacy of Chinese medicine injections in treating transient ischemic attack(TIA) based on network Meta-analysis. Randomized controlled trial(RCT) about Chinese medicine injections in treating TIA were retrieved from PubMed, Web of Science, Cochrane Library, EMbase, CNKI, VIP, Wanfang, and SinoMed with the time interval from inception to March 1, 2024. The methodological quality of the included articles was assessed by ROB 2.0, and the GRADE system was employed to evaluate the quality of evidence. The gemtc package of R 4.1.2 was used to perform the network Meta-analysis. Finally, 63 RCTs with a total sample size of 5 750 cases were included, involving 11 Chinese medicine injections(Shuxuetong Injection, Danhong Injection, Shuxuening Injection, Ginkgo Damo Injection, Shenxiong Glucose Injection, Ligustrazine Injection, Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection, Salvianolic Acids for Injection, Dengzhan Xixin Injection, Guhong Injection, and Xueshuantong Injection). All patients received conventional western medicine treatment, and the experimental group was additionally treated with Chinese medicine injection. Network Meta-analysis yielded the following results.(1) In terms of improving the clinical total response rate, 11 Chinese medicine injections combined with conventional western medicine outperformed conventional western medicine alone, and Dengzhan Xixin Injection + conventional western medicine had the best effect.(2) In terms of reducing plasma viscosity, 7 Chinese medicine injections combined with conventional western medicine outperformed conventional western medicine alone, and Shenxiong Glucose Injection + conventional western medicine had the best effect.(3) In terms of reducing whole blood high shear viscosity, 6 Chinese medicine injections combined with conventional western medicine outperformed conventional western medicine alone, and Guhong Injection + conventional western medicine had the best effect.(4) In terms of reducing whole blood low shear viscosity, 6 Chinese medicine injections combined with conventional western medicine outperformed conventional western medicine alone, and Shuxuening Injection + conventional western medicine had the best effect.(5) In terms of reducing fibrinogen, 9 Chinese medicine injections combined with conventional western medicine outperformed conventional western medicine alone, and Ginkgo Damo Injection + conventional western medicine had the best effect.(6) In terms of increasing the average blood flow velocity, 3 Chinese medicine injections combined with conventional western medicine outperformed conventional western medicine alone, and Shuxuening Injection + conventional western medicine had the best effect. In summary, compared with conventional western medicine alone, Chinese medicine injections combined with conventional western medicine were effective in improving the clinical total response rate and the average blood flow velocity, as well as reducing plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and fibrinogen. However, due to the limited quality and quantity of the included articles, the above conclusions need to be verified by more high-quality, multi-center, and large-sample RCT.

Key Findings

However, due to the limited quality and quantity of the included articles, the above conclusions need to be verified by more high-quality, multi-center, and large-sample RCT.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 63
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Drugs, Chinese Herbal
  • Injections
  • Ischemic Attack, Transient
  • Randomized Controlled Trials as Topic
  • Treatment Outcome

Evidence Classification

  • Level: Other
  • Publication Types: English Abstract, Journal Article, Network Meta-Analysis
  • Vertical: ginkgo

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09