Influence of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease: A meta-analysis

source extracted confidence: high 2026-04-09
#humans #non-alcoholic-fatty-liver-disease #curcumin #randomized-controlled-trials-as-topic #body-mass-index

Influence of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease: A meta-analysis

Liu et al., 2024 | Medicine (Baltimore) | Meta Analysis

Citation

Liu Nana, Li Hongting. Influence of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease: A meta-analysis. Medicine (Baltimore). 2024-Dec-27;103(52):e40538. doi:10.1097/MD.0000000000040538

Abstract

BACKGROUND: Phytosomal curcumin may have some potential in improving anthropometric indices for nonalcoholic fatty liver disease, and this meta-analysis aims to study the effect of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease. METHODS: We have searched several databases including PubMed, EMbase, Web of science, EBSCO and Cochrane library databases, and selected the randomized controlled trials (RCTs) comparing phytosomal curcumin with placebo for nonalcoholic fatty liver disease. This meta-analysis was conducted using the random-effect or fixed-effect model based on the heterogeneity. RESULTS: Seven RCTs were included in this meta-analysis. Compared with placebo in nonalcoholic fatty liver disease, phytosomal curcumin was associated with substantially reduced body mass index (BMI, mean difference [MD] = -0.72; 95% confidence interval [CI] = -1.11 to -0.33; P = .0003), body fat percent (MD = -2.04; 95% CI = -3.10 to -0.98; P = .0002), weight (MD = -2.15; 95% CI = -3.78 to -0.53; P = .01) and waist circumference (MD = -2.09; 95% CI = -4.05 to -0.12; P = .04), but showed no influence on hip circumference (MD = -0.06; 95% CI = -0.59 to 0.47; P = .83) or waist/hip ratio (MD = 0; 95% CI = -0.01 to 0.01; P = 1). CONCLUSIONS: Phytosomal curcumin is effective to improve anthropometric indices for patients with nonalcoholic fatty liver disease.

Key Findings

Seven RCTs were included in this meta-analysis. Compared with placebo in nonalcoholic fatty liver disease, phytosomal curcumin was associated with substantially reduced body mass index (BMI, mean difference [MD] = -0.72; 95% confidence interval [CI] = -1.11 to -0.33; P = .0003), body fat percent (MD = -2.04; 95% CI = -3.10 to -0.98; P = .0002), weight (MD = -2.15; 95% CI = -3.78 to -0.53; P = .01) and waist circumference (MD = -2.09; 95% CI = -4.05 to -0.12; P = .04), but showed no influence on

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population nonalcoholic fatty liver disease
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Non-alcoholic Fatty Liver Disease
  • Curcumin
  • Randomized Controlled Trials as Topic
  • Body Mass Index
  • Waist Circumference
  • Anthropometry
  • Body Weight

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis
  • Vertical: curcumin-metabolic

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09