Collagen Matrix Versus Subepithelial Connective Tissue for Recession Coverage: A Systematic Review

source extracted confidence: high 2026-04-09
#humans #collagen #connective-tissue #gingival-recession

Collagen Matrix Versus Subepithelial Connective Tissue for Recession Coverage: A Systematic Review

Zangani et al., 2025 | Oral Dis | Meta Analysis

Citation

Zangani Alessandro, Gualtieri Miriana, ... Albanese Massimo. Collagen Matrix Versus Subepithelial Connective Tissue for Recession Coverage: A Systematic Review. Oral Dis. 2025-Apr;31(4):1092-1106. doi:10.1111/odi.15203

Abstract

OBJECTIVE: To evaluate the outcome of collagen matrix (CMX) compared with subepithelial connective tissue graft (SCTG) in gingival recession coverage (RC) surgery. METHODS: Review protocol was registered in PROSPERO. The search was conducted on MEDLINE, Cochrane Library, and Scopus databases. Randomized studies comparing CMX versus. SCTG or CMX versus. covering procedures without any filling material, for class I recession treatment were included. Risk of bias assessment and quantitative analysis were performed. RESULTS: Of 168 records, 11 randomized clinical trials were included. The meta-analysis revealed no statistically significant difference in terms of %RC (p = 0.37); there was a statistically significant difference in terms of recession reduction (p = 0.02) and keratinized tissue width (p = 0.03) in favor of SCTG cases. CMX showed a statistically significantly better result compared to no grafting, regarding %RC (p = 0.003) and keratinized tissue thickness (p < 0.0001). The duration of the intervention was significantly shorter for CMX than for SCTG (p < 0.0001). CONCLUSION: CMX can be considered a viable material, especially when a ΔKTt increase and a reduction of intervention duration is needed. The indications for the choice, however, may depend on the individual local condition. PROSPERO Registration: Registration in PROSPERO (International prospective register of systematic reviews): CRD42024555443.

Key Findings

Of 168 records, 11 randomized clinical trials were included. The meta-analysis revealed no statistically significant difference in terms of %RC (p = 0.37); there was a statistically significant difference in terms of recession reduction (p = 0.02) and keratinized tissue width (p = 0.03) in favor of SCTG cases. CMX showed a statistically significantly better result compared to no grafting, regarding %RC (p = 0.003) and keratinized tissue thickness (p < 0.0001). The duration of the intervention wa

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Collagen
  • Connective Tissue
  • Gingival Recession

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Comparative Study, Journal Article, Meta-Analysis, Systematic Review
  • Vertical: collagen

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09