Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials

source extracted confidence: high 2026-04-09
#humans #dietary-supplements #randomized-controlled-trials-as-topic #blood-glucose #adult

Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials

Zhang et al., 2025 | Crit Rev Food Sci Nutr | Meta Analysis

Citation

Zhang Jiaqi, Poon Eric Tsz-Chun, Wong Stephen Heung-Sang. Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials. Crit Rev Food Sci Nutr. 2025;65(22):4382-4400. doi:10.1080/10408398.2024.2387324

Abstract

A surge of public interest in NMN supplementation has been observed in recent years. However, whether NMN supplements are effective in improving metabolic health remains unclear. The objective of the review was to assess the effects of NMN supplementation on fasting glucose, triglycerides, total cholesterol, LDL-C, and HDL-C in adults. Studies were located by searching four databases (PubMed, Embase, Cochrane, and Web of Science). Two reviewers independently conducted title/abstract and full-text screening, data extraction, and risk-of-bias assessment. Of the 4049 records reviewed, 12 studies with a total of 513 participants met the criteria for analysis. Random-effects meta-analyses found an overall significant effect of NMN supplementation in elevating blood NAD levels. However, most of the clinically relevant outcomes were not significantly different between NMN supplementation and control group. Risk-of-bias assessment using RoB2 showed some concerns in seven studies and high risk of bias in the other five studies. Together, our findings suggest that an exaggeration of the benefits of NMN supplementation may exist in the field. Although the limited number of eligible studies was sufficiently powered to detect changes in the abovementioned primary outcomes, more studies are needed to conclude about the exact effects of NMN supplementation.

Key Findings

Although the limited number of eligible studies was sufficiently powered to detect changes in the abovementioned primary outcomes, more studies are needed to conclude about the exact effects of NMN supplementation.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 513
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Dietary Supplements
  • Randomized Controlled Trials as Topic
  • Blood Glucose
  • Adult
  • Lipid Metabolism
  • Triglycerides
  • NAD
  • Administration, Oral

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: nmn

Provenance

Source extracted via PubMed E-utilities API on 2026-04-10