Resveratrol and male infertility: a systematic review of the literature

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#resveratrol #male #humans #infertility-male #spermatozoa

Resveratrol and male infertility: a systematic review of the literature

Cannarella et al., 2025 | Minerva Endocrinol (Torino) | Systematic Review

Citation

Cannarella Rossella, Mehta Poonam, ... Rajender Singh. Resveratrol and male infertility: a systematic review of the literature. Minerva Endocrinol (Torino). 2025-Sep;50(3):312-321. doi:10.23736/S2724-6507.23.04099-X

Abstract

INTRODUCTION: The aim of this study is to provide an updated and comprehensive systematic review on the effects of resveratrol (RSV) in male infertility and sperm preservation. EVIDENCE ACQUISITION: This systematic review followed the MOOSE guidelines for Meta-analyses and Systematic Reviews of Observational Studies and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P). Only original articles evaluating the effect of RSV on human spermatozoa in vivo or in vitro were included. EVIDENCE SYNTHESIS: Of the 1806 abstracts evaluated for eligibility, only 12 studies were included in the qualitative synthesis, of which three were prospective in-vivo studies and nine were in-vitro studies. Out of three human studies on RSV, only two studies administered RSV alone, one of them reported a positive impact and the other reported no significant impact on semen parameters. Overall, the in-vitro studies have reported the ability of RSV to protect spermatozoa against damage due to freeze-thaw cycles during cryopreservation. Other in-vitro studies have reported positive effects of RSV in fresh samples and protective effects in cell lines. CONCLUSIONS: Available in-vivo studies are controversial with regard to the effect of RSV in improving semen parameters. In-vitro studies support the use of RSV before sperm cryopreservation. Further well-designed prospective studies on large sample sizes are needed to fully understand the role of RSV in the treatment of male infertility in vivo.

Key Findings

Available in-vivo studies are controversial with regard to the effect of RSV in improving semen parameters. In-vitro studies support the use of RSV before sperm cryopreservation. Further well-designed prospective studies on large sample sizes are needed to fully understand the role of RSV in the treatment of male infertility in vivo.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 12
Age Range See abstract
Condition See abstract

MeSH Terms

  • Resveratrol
  • Male
  • Humans
  • Infertility, Male
  • Spermatozoa
  • Semen Preservation
  • Cryopreservation
  • Antioxidants

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09