A systematic review of randomized controlled trials related to the effects of garlic supplementation on platelet aggregation

source extracted confidence: high 2026-04-09
#humans #garlic #platelet-aggregation #randomized-controlled-trials-as-topic #antioxidants

A systematic review of randomized controlled trials related to the effects of garlic supplementation on platelet aggregation

Mollahosseini et al., 2022 | Phytother Res | Systematic Review

Citation

Mollahosseini Mehdi, Hosseini-Marnani Elham, ... Mozaffari-Khosravi Hassan. A systematic review of randomized controlled trials related to the effects of garlic supplementation on platelet aggregation. Phytother Res. 2022-Nov;36(11):4041-4050. doi:10.1002/ptr.7556

Abstract

The increment of platelet aggregation factors has been considered a key phenomenon in atherosclerosis. Studies have shown that garlic (Allium sativum) is associated with a reduction in platelet aggregation and thrombosis. Hence, the present systematic review was conducted to evaluate the effect of garlic on platelet aggregation. All randomized controlled trials (RCTs) with keywords related to garlic and platelet aggregation were thoroughly searched in electronic databases including PubMed, Scopus, ISI Web of Science, and Google Scholar up to January 2021. Moreover, the references of all related articles were screened to discover more relevant studies. The quality of each study was reported based on Cochrane Collaboration's tool. In total, 12 studies met the inclusion criteria from 18,235 identified articles (including 595 participants). Most of the studies assessed platelet aggregation in response to different inducers. Of the 12 clinical trials, six studies depicted the beneficial effect of garlic on reducing platelet aggregation. The summary of the quality assessment indicated that most of the studies had high-quality scores. Regarding the small number of RCTs and heterogeneity between studies, it is impossible to make a proper conclusion about the impacts of garlic on platelet aggregation. Therefore, further precise trials with a standard design are necessary to validate the anti-thrombotic effect of garlic.

Key Findings

Therefore, further precise trials with a standard design are necessary to validate the anti-thrombotic effect of garlic.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 595
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Garlic
  • Platelet Aggregation
  • Randomized Controlled Trials as Topic
  • Antioxidants
  • Biological Products
  • Dietary Supplements

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: garlic

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09