Relationship between serum vitamin D and hip fracture in the elderly: a systematic review and meta-analysis

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#aged #cohort-studies #hip-fractures #humans #vitamin-d

Relationship between serum vitamin D and hip fracture in the elderly: a systematic review and meta-analysis

Habibi et al., 2022 | J Bone Miner Metab | Meta Analysis

Citation

Habibi Ghahfarrokhi Shahrzad, Mohammadian-Hafshejani Abdollah, ... Heidari-Soureshjani Saeid. Relationship between serum vitamin D and hip fracture in the elderly: a systematic review and meta-analysis. J Bone Miner Metab. 2022-Jul;40(4):541-553. doi:10.1007/s00774-022-01333-7

Abstract

INTRODUCTION: This study investigated the relationship between serum 25-hydroxyvitamin D (25OHD) levels and the occurrence of hip fractures in the elderly using a systematic review and meta-analysis approach. MATERIALS AND METHODS: PubMed, Web of Science, and Scopus were used to identify studies that outlined an association between serum 25OHD and the occurrence of a hip fracture in a geriatric patient. The analysis calculated odds ratios (OR) for a hip fracture using a random-effects model. RESULTS: In this study, 28 studies were included, 61,744 elderlies and 9767 cases (15.81%) of hip fractures. In the lowest vs. highest categories of vitamin D in the elderly, pooled OR of hip fractures was 1.80 (95% CI 1.56-2.07, P ≤ 0.001), and modified OR was equal to 1.40 (95% CI 1.20-1.63 P ≤ 0.001). A subgroup analysis showed that the OR of a hip fracture was 2.16 (1.49-3.11, P ≤ 0.001) in case-control studies; 1.52 (1.29-1.79, P = 0.001) in cohort studies; and 1.41 (1.18-1.70, P ≤ 0.001) in case-cohort studies. CONCLUSION: Low serum vitamin D levels in the elderly are associated with an increase in the odds of hip fracture.

Key Findings

In this study, 28 studies were included, 61,744 elderlies and 9767 cases (15.81%) of hip fractures. In the lowest vs. highest categories of vitamin D in the elderly, pooled OR of hip fractures was 1.80 (95% CI 1.56-2.07, P ≤ 0.001), and modified OR was equal to 1.40 (95% CI 1.20-1.63 P ≤ 0.001). A subgroup analysis showed that the OR of a hip fracture was 2.16 (1.49-3.11, P ≤ 0.001) in case-control studies; 1.52 (1.29-1.79, P = 0.001) in cohort studies; and 1.41 (1.18-1.70, P ≤ 0.001) in case-co

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 28
Age Range See abstract
Condition See abstract

MeSH Terms

  • Aged
  • Cohort Studies
  • Hip Fractures
  • Humans
  • Vitamin D
  • Vitamin D Deficiency
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-d-falls

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09