Effects of vitamin E and vitamin C on male infertility: a meta-analysis

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#ascorbic-acid #female #humans #infertility-male #male

Effects of vitamin E and vitamin C on male infertility: a meta-analysis

Zhou et al., 2022 | Int Urol Nephrol | Meta Analysis

Citation

Zhou Xianling, Shi Heng, ... Sun Shengyun. Effects of vitamin E and vitamin C on male infertility: a meta-analysis. Int Urol Nephrol. 2022-Aug;54(8):1793-1805. doi:10.1007/s11255-022-03237-x

Abstract

PURPOSE: The efficacy of the antioxidants vitamin E (VitE) and vitamin C (VitC) on male infertility is uncertain. Therefore, this research systematically assessed the influences of VitE and VitC on male infertility. METHODS: We did a meta-analysis of randomized controlled trials (RCTs) to analyze semen parameters, pregnancy rate, and adverse effects (AEs) between VitE and VitC groups and control groups by searching Cochrane Library, Excerpta Medica Database (Embase), PubMed, China Biology Medicine disc (CBMdisc), and Web of Science up to June 2020. RESULTS: We screened 11 studies (832 patients) that met the inclusion criteria. The evidence quality ranged from moderate to low. The pregnancy rate was obviously better in the VitE group than in the control group (relative risk (RR) 1.86, 95% confidence interval (CI) 1.02-3.41). Compared with the control group, VitE and VitC significantly improved progressive motility (standardized mean difference (SMD) 0.38, 95% CI 0.22-0.55), sperm concentration (SMD 0.21, 95% CI 0.09-0.34), sperm morphology (SMD 0.32, 95% CI 0.09-0.55), and total sperm number (SMD 0.28, 95% CI 0.12-0.43) without AEs. CONCLUSION: This study suggests that VitC and VitE can improve the spousal pregnancy rate and semen parameters in infertile men without AEs.

Key Findings

We screened 11 studies (832 patients) that met the inclusion criteria. The evidence quality ranged from moderate to low. The pregnancy rate was obviously better in the VitE group than in the control group (relative risk (RR) 1.86, 95% confidence interval (CI) 1.02-3.41). Compared with the control group, VitE and VitC significantly improved progressive motility (standardized mean difference (SMD) 0.38, 95% CI 0.22-0.55), sperm concentration (SMD 0.21, 95% CI 0.09-0.34), sperm morphology (SMD 0.32

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 832
Age Range See abstract
Condition See abstract

MeSH Terms

  • Ascorbic Acid
  • Female
  • Humans
  • Infertility, Male
  • Male
  • Pregnancy
  • Randomized Controlled Trials as Topic
  • Semen
  • Sperm Count
  • Vitamin E
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis
  • Vertical: vitamin-c

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09