Serum Vitamin D Level and Erectile Dysfunction in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

source extracted confidence: high 2026-04-09
#diabetes-mellitus-type-2 #erectile-dysfunction #humans #male #risk-factors

Serum Vitamin D Level and Erectile Dysfunction in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Liu et al., 2022 | Urol Int | Meta Analysis

Citation

Liu Guodong, Wu Xu, ... Zhang Xiansheng. Serum Vitamin D Level and Erectile Dysfunction in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Urol Int. 2022;106(10):1025-1032. doi:10.1159/000523691

Abstract

INTRODUCTION: A few studies involved the relationship between vitamin D and diabetes mellitus (DM) with erectile dysfunction (ED), and no meta-analysis was conducted to pool these data. The main purpose of our study was to examine the changes in serum vitamin D levels in patients with DM combined with ED. METHODS: An extensive search was performed, including the following words: "erectile dysfunction," "diabetes," and "vitamin D." Databases, including Cochrane Library, PubMed, and Web of Science, were retrieved to identify studies published up to September 30, 2021. Four studies were eligible for our meta-analysis. RESULTS: The weighted mean difference and their corresponding 95% confidence intervals were calculated to the data we selected. The results showed that the level of vitamin D in DM with ED was significantly lower (12.5 nmol/mL) than patients with diabetes alone (p = 0.002). CONCLUSION: Our novel meta-analysis suggests that vitamin D may be a risk factor for DM with ED, which can provide a new idea for the treatment and prevention of DM with ED.

Key Findings

The weighted mean difference and their corresponding 95% confidence intervals were calculated to the data we selected. The results showed that the level of vitamin D in DM with ED was significantly lower (12.5 nmol/mL) than patients with diabetes alone (p = 0.002).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population dm combined with ed
Sample Size See abstract
Age Range See abstract
Condition diabetes

MeSH Terms

  • Diabetes Mellitus, Type 2
  • Erectile Dysfunction
  • Humans
  • Male
  • Risk Factors
  • Vitamin D
  • Vitamin D Deficiency
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09