COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials

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#covid-19 #cause-of-death #humans #randomized-controlled-trials-as-topic #vitamin-d

COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials

Varikasuvu et al., 2022 | Expert Rev Anti Infect Ther | Meta Analysis

Citation

Varikasuvu Seshadri Reddy, Thangappazham Balachandar, ... Aloori Sowjanya. COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Expert Rev Anti Infect Ther. 2022-Jun;20(6):907-913. doi:10.1080/14787210.2022.2035217

Abstract

INTRODUCTION: Vitamin D levels have been reported to be associated with COVID-19 susceptibility, severity, and mortality events. We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the use of vitamin D intervention on COVID-19 outcomes. AREAS COVERED: Literature search was conducted using PubMed, Cochrane library, and ClinicalTrials.gov databases. We included RCTs reporting the use of vitamin D intervention to control/placebo group in COVID-19. The study was registered at PROSPERO: CRD42021271461. EXPERT OPINION: A total of 6 RCTs with 551 COVID-19 patients were included. The overall collective evidence pooling all the outcomes across all RCTs indicated the beneficial use of vitamin D intervention in COVID-19 (relative risk, RR = 0.60, 95% CI 0.40 to 0.92, Z = 2.33, p = 0.02, I2 = 48%). The rates of RT-CR positivity were significantly decreased in the intervention group as compared to the non-vitamin D groups (RR = 0.46, 95% CI 0.24 to 0.89, Z = 2.31, p = 0.02, I2 = 0%). Conclusively, COVID-19 patients supplemented with vitamin D are more likely to demonstrate fewer rates of ICU admission, mortality events, and RT-PCR positivity.

Key Findings

Conclusively, COVID-19 patients supplemented with vitamin D are more likely to demonstrate fewer rates of ICU admission, mortality events, and RT-PCR positivity.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 19
Age Range See abstract
Condition See abstract

MeSH Terms

  • COVID-19
  • Cause of Death
  • Humans
  • Randomized Controlled Trials as Topic
  • Vitamin D
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09