The Impact of Selenium Supplementation on Trauma Patients-Systematic Review and Meta-Analysis

source extracted confidence: high 2026-04-09
#adult #clinical-trials-as-topic #critical-care #critical-care-outcomes #dietary-supplements

The Impact of Selenium Supplementation on Trauma Patients-Systematic Review and Meta-Analysis

Huang et al., 2022 | Nutrients | Meta Analysis

Citation

Huang Jen-Fu, Hsu Chih-Po, ... Hsieh Chi-Hsun. The Impact of Selenium Supplementation on Trauma Patients-Systematic Review and Meta-Analysis. Nutrients. 2022-Jan-14;14(2). doi:10.3390/nu14020342

Abstract

This study aimed to assess current evidence regarding the effect of selenium (Se) supplementation on the prognosis in patients sustaining trauma. MEDLINE, Embase, and Web of Science databases were searched with the following terms: "trace element", "selenium", "copper", "zinc", "injury", and "trauma". Seven studies were included in the meta-analysis. The pooled results showed that Se supplementation was associated with a lower mortality rate (OR 0.733, 95% CI: 0.586, 0.918, p = 0.007; heterogeneity, I2 = 0%). Regarding the incidence of infectious complications, there was no statistically significant benefit after analyzing the four studies (OR 0.942, 95% CI: 0.695, 1.277, p = 0.702; heterogeneity, I2 = 14.343%). The patients with Se supplementation had a reduced ICU length of stay (standard difference in means (SMD): -0.324, 95% CI: -0.382, -0.265, p < 0.001; heterogeneity, I2 = 0%) and lesser hospital length of stay (SMD: -0.243, 95% CI: -0.474, -0.012, p < 0.001; heterogeneity, I2 = 45.496%). Se supplementation after trauma confers positive effects in decreasing the mortality and length of ICU and hospital stay.

Key Findings

Se supplementation after trauma confers positive effects in decreasing the mortality and length of ICU and hospital stay.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population se supplementation had a
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adult
  • Clinical Trials as Topic
  • Critical Care
  • Critical Care Outcomes
  • Dietary Supplements
  • Female
  • Humans
  • Intensive Care Units
  • Length of Stay
  • Male
  • Middle Aged
  • Prognosis
  • Selenium
  • Trace Elements
  • Treatment Outcome
  • Wounds and Injuries

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: zinc

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09