Can resveratrol modulate sirtuins in obesity and related diseases? A systematic review of randomized controlled trials

source extracted confidence: high 2026-04-09
#diet #humans #obesity #randomized-controlled-trials-as-topic #resveratrol

Can resveratrol modulate sirtuins in obesity and related diseases? A systematic review of randomized controlled trials

Fraiz et al., 2021 | Eur J Nutr | Systematic Review

Citation

Fraiz Gabriela Macedo, da Conceição Aline Rosignoli, ... Hermsdorff Helen Hermana Miranda. Can resveratrol modulate sirtuins in obesity and related diseases? A systematic review of randomized controlled trials. Eur J Nutr. 2021-Sep;60(6):2961-2977. doi:10.1007/s00394-021-02623-y

Abstract

PURPOSE: Human sirtuins can be a powerful therapeutic target in preventing and treating obesity and age-related diseases. Some dietary components can modulate sirtuins' activity, such as resveratrol. This systematic review aimed to assess whether resveratrol (RSV), without other interventions, can stimulate sirtuins in the treatment of excess weight and its comorbidities. METHODS: MEDLINE/Pubmed, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) were used for search eligible articles. Randomized clinical trials assessing RSV supplementation on changes in the sirtuins' gene expression/protein levels was the primary outcome. Other possible changes in cardiometabolic markers were considered the second outcome. Following PRISMA guidelines and using predefined inclusion and exclusion criteria, two reviewers independently and in parallel screened, assessed the studies' quality, and compiled data. Disagreements were resolved by consensus or consulting a third author. RESULTS: This review included seven randomized control trials. Four articles demonstrated a significant increase in SIRT-1 with different RSV dosages and interventions time. The secondary outcomes showed improvements in insulin sensitivity, lipid profile, metabolic flexibility, total antioxidant capacity, energy expenditure changes, and reduction of ectopic accumulation of fat. CONCLUSION: Data from RCTs studies showed that RSV supplementation could stimulate SIRT-1 in humans, and therefore contribute to the treatment of excess weight and its comorbidities. However, more research is needed because it was not possible to confirm this effect truly. [PROSPERO registration number: CRD42020205571].

Key Findings

This review included seven randomized control trials. Four articles demonstrated a significant increase in SIRT-1 with different RSV dosages and interventions time. The secondary outcomes showed improvements in insulin sensitivity, lipid profile, metabolic flexibility, total antioxidant capacity, energy expenditure changes, and reduction of ectopic accumulation of fat.

Outcomes Measured

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Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Diet
  • Humans
  • Obesity
  • Randomized Controlled Trials as Topic
  • Resveratrol
  • Sirtuins

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09