Systematic review and meta-analyses of vitamin E (alpha-tocopherol) supplementation and blood lipid parameters in patients with diabetes mellitus

Mohammad et al., 2021 | Diabetes Metab Syndr | Meta Analysis

Citation

Mohammad Abolfathi, Falahi Ebrahim, ... Rezaie Farahnaz. Systematic review and meta-analyses of vitamin E (alpha-tocopherol) supplementation and blood lipid parameters in patients with diabetes mellitus. Diabetes Metab Syndr. 2021;15(4):102158. doi:10.1016/j.dsx.2021.05.031

Abstract

BACKGROUND AND AIMS: The studies have shown that α-tocopherol supplementation could improve lipid profile in diabetes mellitus (DM) patients. Nonetheless, the result remains inconsistent. Therefore, this meta-analysis was performed to evaluate the efficacy of α-tocopherol supplement on lipid parameters in DM patients. METHODS: We conducted an extensive search via Cochrane Library, PubMed, Scopus, and Web of Science databases to acquire the reported RCTs up to October 2020. RESULTS: The results showed no effects of α-tocopherol supplementation on lipid profile in DM patients except when used ≥12 weeks. CONCLUSIONS: α-tocopherol supplementation in DM patients had no significant effect on lipid profiles.

Key Findings

The results showed no effects of α-tocopherol supplementation on lipid profile in DM patients except when used ≥12 weeks.

Outcomes Measured

Requires manual extraction

Population

Field	Value
Population	See abstract
Sample Size	See abstract
Age Range	See abstract
Condition	diabetes

MeSH Terms

Diabetes Mellitus
Dietary Supplements
Humans
Lipids
Randomized Controlled Trials as Topic
alpha-Tocopherol

Evidence Classification

Level: Meta Analysis
Publication Types: Journal Article, Meta-Analysis, Systematic Review
Vertical: vitamin-e

Provenance

PMID: 34186370
DOI: 10.1016/j.dsx.2021.05.031
PMCID: Not in PMC
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09