Can vitamin D be considered an adiponectin secretagogue? A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#adiponectin #humans #randomized-controlled-trials-as-topic #secretagogues #vitamin-d

Can vitamin D be considered an adiponectin secretagogue? A systematic review and meta-analysis

Nikooyeh et al., 2021 | J Steroid Biochem Mol Biol | Meta Analysis

Citation

Nikooyeh Bahareh, Neyestani Tirang R. Can vitamin D be considered an adiponectin secretagogue? A systematic review and meta-analysis. J Steroid Biochem Mol Biol. 2021-Sep;212:105925. doi:10.1016/j.jsbmb.2021.105925

Abstract

There is some evidence for ameliorating effect of vitamin D on glycemic and lipidemic status which are likely to be mediated through other molecules including adiponectin. However, the overall results have been controversial. This study was conducted to evaluate the effect of vitamin D supplementation on serum adiponectin concentration. MEDLINE, PubMed, Embase, Cochrane Library, and Google Scholar were searched and 402 studies were found in a preliminary search. After screening of titles and abstracts nine studies were selected. Pooled data showed no significant effect on adiponectin concentrations (mean difference (MD) 0.37, 95 % CI: -0.1 to 0.87). However, there was a significant effect in a subgroup of participants who had diabetes (MD: 0.03, 95 % CI: 0.00 to 0.05, p = 0.029). The treatment effect on adiponectin concentrations was significant in those trials that used supplementation on a daily basis (MD: 0.03, 95 % CI: 0.00 to 0.05, p = 0.028) and vitamin D plus calcium (MD: 0.04, 95 % CI: 0.01 to 0.07, p = 0.014). The meta-regression revealed a significant association between BMI and age of participants at baseline and the treatment effect (B, -0.144, 95 % CI: -0.276 to -0.011, p = 0.033 and B, -0.043, 95 % CI: -0.075 to -0.012, p = 0.006). The results of this meta-analysis study indicates that vitamin D may be considered an adiponectin secretagogue in subjects with diabetes and this effect may be potentiated if vitamin D intake is on daily basis and in combination with calcium but can be weakened by increasing BMI.

Key Findings

The results of this meta-analysis study indicates that vitamin D may be considered an adiponectin secretagogue in subjects with diabetes and this effect may be potentiated if vitamin D intake is on daily basis and in combination with calcium but can be weakened by increasing BMI.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population diabetes and this effect
Sample Size 402
Age Range See abstract
Condition diabetes

MeSH Terms

  • Adiponectin
  • Humans
  • Randomized Controlled Trials as Topic
  • Secretagogues
  • Vitamin D
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09