Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#dietary-supplements #humans #migraine-disorders #pain #randomized-controlled-trials-as-topic

Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis

Chen et al., 2022 | Nutr Neurosci | Meta Analysis

Citation

Chen Yu-Shiue, Lee Huan-Fang, ... Hu Fang-Wen. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022-Sep;25(9):1801-1812. doi:10.1080/1028415X.2021.1904542

Abstract

OBJECTIVE: Migraine is a common disease worldwide and migraine prevention is primarily currently based on pharmaceuticals. The mechanism of Vitamin B2 may positively contribute to migraine. This systematic review and meta-analysis aimed to evaluate the impact of Vitamin B2 supplementation on the days, duration, frequency, and pain score of the migraine attack. METHODS: : The PRISMA guideline was used for the studying process. Five electronic databases, PubMed, Embase, Cochrane, CINAHL, and CEPS were searched from 1990 to March 2019. The search terms were Vitamin B2, migraine, and prophylactic. A meta-analysis was performed using Comprehensive Meta-Analysis (CMA) version. RESULTS: : Nine articles were included in systemic review and finally meta-analysis. Eight randomized controlled trials and one controlled clinical trial with 673 subjects were analyzed using meta-analysis. Vitamin B2 supplementation significantly decreased migraine days (p = .005, I2 = 89%), duration (p = .003, I2 = 0), frequency (p = .001, I2 = 65%), and pain score (p = .015, I2 = 84%). CONCLUSIONS: A pooled analysis of available randomized controlled clinical trials demonstrated that Vitamin B2 400 mg/day for three months supplementation had significant effect on days, duration, frequency, and pain score of migraine attacks.

Key Findings

: Nine articles were included in systemic review and finally meta-analysis. Eight randomized controlled trials and one controlled clinical trial with 673 subjects were analyzed using meta-analysis. Vitamin B2 supplementation significantly decreased migraine days (p = .005, I2 = 89%), duration (p = .003, I2 = 0), frequency (p = .001, I2 = 65%), and pain score (p = .015, I2 = 84%).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 673
Age Range See abstract
Condition See abstract

MeSH Terms

  • Dietary Supplements
  • Humans
  • Migraine Disorders
  • Pain
  • Randomized Controlled Trials as Topic
  • Riboflavin

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: riboflavin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-10