Vitamin D status and efficacy of vitamin D supplementation in acne patients: A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#acne-vulgaris #adolescent #dietary-supplements #humans #randomized-controlled-trials-as-topic

Vitamin D status and efficacy of vitamin D supplementation in acne patients: A systematic review and meta-analysis

Wang et al., 2021 | J Cosmet Dermatol | Meta Analysis

Citation

Wang Meng, Zhou Yuan, Yan Yan. Vitamin D status and efficacy of vitamin D supplementation in acne patients: A systematic review and meta-analysis. J Cosmet Dermatol. 2021-Dec;20(12):3802-3807. doi:10.1111/jocd.14057

Abstract

BACKGROUND: Acne vulgaris, a chronic inflammatory dermatosis, affects approximately 85% of adolescents and young adults.The level of vitamin D in acne patients and the effect on acne patients of a vitamin D supplementation have previously been documented; however, it remains to be disputed whether vitamin D deficiency is normal in acne patients. AIMS: This paper explores the relationship between vitamin D and acne levels and the advantageous implications of vitamin D supplements on acne. METHODS: From every database start date until December 2020, we checked the PubMed, EMBASE, MEDLINE and the Cochrane libraries. Case-controls or randomized controlled trial reporting on the serum 25(OH)D level and the efficacy of vitamin D supplement to acne patients were included. RESULTS: The serum 25(OH)D levels in acne patients is lower (standardized mean difference = -7.66 ng/ml; 95% confidence interval (CI) = -10.92 to -4.40). Articles also revealed the prospect of a therapeutic breakthrough through the supplementing of vitamin D for acne patients. CONCLUSION: Our research offers a new guide in the field of acne prevention and health care.

Key Findings

The serum 25(OH)D levels in acne patients is lower (standardized mean difference = -7.66 ng/ml; 95% confidence interval (CI) = -10.92 to -4.40). Articles also revealed the prospect of a therapeutic breakthrough through the supplementing of vitamin D for acne patients.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition deficiency

MeSH Terms

  • Acne Vulgaris
  • Adolescent
  • Dietary Supplements
  • Humans
  • Randomized Controlled Trials as Topic
  • Vitamin D
  • Vitamin D Deficiency
  • Vitamins
  • Young Adult

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09