Vitamin D supplementation in patients with cystic fibrosis: A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#cystic-fibrosis #humans #randomized-controlled-trials-as-topic #vitamin-d

Vitamin D supplementation in patients with cystic fibrosis: A systematic review and meta-analysis

Juhász et al., 2021 | J Cyst Fibros | Meta Analysis

Citation

Juhász Márk Félix, Varannai Orsolya, ... Párniczky Andrea. Vitamin D supplementation in patients with cystic fibrosis: A systematic review and meta-analysis. J Cyst Fibros. 2021-Sep;20(5):729-736. doi:10.1016/j.jcf.2020.12.008

Abstract

Despite routine supplementation, vitamin D insufficiency is often seen in cystic fibrosis (CF) patients on account of pancreatic insufficiency. Vitamin D is a crucial component of bone health and affects nearly all cells of the immune system. However, clinical benefits or harms associated with supplementation are poorly documented. In this systematic review, we included randomized controlled trials (RCTs) that compared vitamin D supplementation with placebo (i.e. 'non-increased dose') in CF patients. Analysing the 8 included RCTs, the intervention group had significantly higher serum 25-hydroxyvitamin D (se25OHD) levels, but there were no significant differences found in the quantitative synthesis of clinical outcomes, including bone disease-, respiratory status- and immunological status-related outcomes. Based on our current results, while a higher vitamin D dose elevates se25OHD, it does not seem to influence clinical outcomes. Future RCTs should include outcomes of past studies and apply longer follow-up periods to document long-term patient-important outcomes.

Key Findings

Future RCTs should include outcomes of past studies and apply longer follow-up periods to document long-term patient-important outcomes.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Cystic Fibrosis
  • Humans
  • Randomized Controlled Trials as Topic
  • Vitamin D

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09