A Systematic Review and Meta-Analysis of Methods Used to Reduce Infectious Complications Following Transrectal Prostate Biopsy

Jazayeri et al., 2020 | Urology | Meta Analysis

Citation

Jazayeri Seyed Behzad, Kumar Jatinder, ... Balaji K C. A Systematic Review and Meta-Analysis of Methods Used to Reduce Infectious Complications Following Transrectal Prostate Biopsy. Urology. 2020-Oct;144:21-27. doi:10.1016/j.urology.2020.06.005

Abstract

We reviewed and analyzed the most effective methods to reduce infectious complications (IC) after transrectal prostate biopsy (TRPB). We included only prospective randomized-controlled trials in the analysis. The analysis neither demonstrated any superiority of fluoroquinolones over other antibiotic classes nor of targeted antibiotics over empiric regimens in men undergoing TRPB. However, longer course antibiotics (3 days or more) compared to single dose or day regimens, combination of fluoroquinolones with aminoglycosides compared to fluoroquinolones alone and povidone-iodine rectal cleansing compared to control significantly reduced IC following TRPB. A combination of addition of aminoglycosides to oral antibiotics for 3 days along with povidone-iodine rectal cleansing may be an optimum strategy to minimize the risk of IC after TRPB.

Key Findings

A combination of addition of aminoglycosides to oral antibiotics for 3 days along with povidone-iodine rectal cleansing may be an optimum strategy to minimize the risk of IC after TRPB.

Outcomes Measured

• Requires manual extraction

Population

MeSH Terms

• Anti-Bacterial Agents
• Bacterial Infections
• Biopsy
• Humans
• Male
• Postoperative Complications
• Prostate
• Rectum

Evidence Classification

• Level: Meta Analysis
• Publication Types: Journal Article, Meta-Analysis, Systematic Review
• Vertical: iodine

Provenance

• PMID: 32569659
• DOI: 10.1016/j.urology.2020.06.005
• PMCID: Not in PMC
• Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09