Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#alzheimer-disease #dietary-supplements #disease-progression #humans #randomized-controlled-trials-as-topic

Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis

Wang et al., 2021 | Nutr Neurosci | Meta Analysis

Citation

Wang Wanyu, Li Jiao, ... Zhang Xiaofeng. Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis. Nutr Neurosci. 2021-Jan;24(1):13-22. doi:10.1080/1028415X.2019.1585506

Abstract

Objective: The association between vitamin E supplementation and Alzheimer's disease (AD) was controversial because of conflicting data in the literature. This study was designed to systematically evaluate evidence about the efficacy of vitamin E supplementation not only on the risk but also on the progression of AD. Design: Five electronic databases were searched for studies published up to June 2017. Articles reporting vitamin E supplementation and AD were included, and the random-effect model was performed for the meta-analysis about the relationship between vitamin E supplementation and AD. Results: Five cohort studies and three randomized controlled trial (RCT) studies (total n = 14,262) involving 1313 cases about vitamin E effects on the risk of AD and 244 cases about effects on progression of AD. The pooled RR for vitamin E supplemental and risk of AD was 0.81 [95% CI: 0.50-1.33, I 2 = 69.2%]. Suitable data could not be extracted to do meta-analysis as there was no unified standard of outcome measure for studies on AD progression. We carefully analyzed and evaluated the authenticity and accuracy of every single trial, while reliable evidence could not be obtained. Conclusions: From what we do, neither the synthetic data on risk of AD nor the critical review on progression of AD could provide enough evidence on our research. Thus, we cannot draw a specific conclusion on the association or correlation between Vitamin E and AD.

Key Findings

Five cohort studies and three randomized controlled trial (RCT) studies (total n = 14,262) involving 1313 cases about vitamin E effects on the risk of AD and 244 cases about effects on progression of AD. The pooled RR for vitamin E supplemental and risk of AD was 0.81 [95% CI: 0.50-1.33, I 2 = 69.2%]. Suitable data could not be extracted to do meta-analysis as there was no unified standard of outcome measure for studies on AD progression. We carefully analyzed and evaluated the authenticity and

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 14262
Age Range See abstract
Condition See abstract

MeSH Terms

  • Alzheimer Disease
  • Dietary Supplements
  • Disease Progression
  • Humans
  • Randomized Controlled Trials as Topic
  • Treatment Outcome
  • Vitamin E

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-e

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09