Vitamin D and Urinary Tract Infection: A Systematic Review and Meta-Analysis

Deng et al., 2019 | Ann Clin Lab Sci | Meta Analysis

Citation

Deng Qi-Fei, Chu Han, ... Cao Yong-Sheng. Vitamin D and Urinary Tract Infection: A Systematic Review and Meta-Analysis. Ann Clin Lab Sci. 2019-Jan;49(1):134-142

Abstract

Whether or not Vitamin D deficiency is associated with urinary tract infections (UTI) remains controversial. We retrieved relevant articles from the PubMed, Google Scholar, the Cochrane Library, Med-line and Embase databases up to Mach 1, 2018 for studies investigating the association between Vitamin D and UTI. The meta-analysis of 9 studies included 1921 participants, of which 580 were diagnosed with UTI. They showed that Vitamin D insufficiency was associated with a significantly increased risk of having a UTI (pooled OR=3.01, 95%CI=2.31-3.91), with moderate heterogeneity (I2 =49.5%). Moreover, Vitamin D level was significantly lower in the UTI group (standardized mean difference (SMD)=-1.65, 95%CI=-2.69--0.60, P<0.001). Significant heterogeneity was also detected (I2 =97.9%, P<0.001). Meta-analysis also revealed a significant association between UTI and Vitamin D deficiency in children (OR=4.78, 95%CI=3.08-7.44, P<0.001). This meta-analysis indicated a significant association between Vitamin D insufficiency and increased risk of UTI, especially in children.

Key Findings

This meta-analysis indicated a significant association between Vitamin D insufficiency and increased risk of UTI, especially in children.

Outcomes Measured

• Requires manual extraction

Population

MeSH Terms

• Humans
• Prognosis
• Risk Factors
• Urinary Tract Infections
• Vitamin D Deficiency

Evidence Classification

• Level: Meta Analysis
• Publication Types: Journal Article, Meta-Analysis, Systematic Review
• Vertical: vitamin-d

Provenance

• PMID: 30814089
• DOI: (not available)
• PMCID: Not in PMC
• Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09