The effectiveness of creatine treatment for Parkinson's disease: an updated meta-analysis of randomized controlled trials

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#activities-of-daily-living #creatine #humans #parkinson-disease #randomized-controlled-trials-as-topic

The effectiveness of creatine treatment for Parkinson's disease: an updated meta-analysis of randomized controlled trials

Mo et al., 2017 | BMC Neurol | Meta Analysis

Citation

Mo Jia-Jie, Liu Lin-Ying, ... Cui Li-Li. The effectiveness of creatine treatment for Parkinson's disease: an updated meta-analysis of randomized controlled trials. BMC Neurol. 2017-Jun-02;17(1):105. doi:10.1186/s12883-017-0885-3

Abstract

BACKGROUND: The effectiveness of creatine in treating Parkinson's disease (PD) has not been conclusively determined. Therefore, we performed a meta-analysis to address this issue. METHODS: The Cochrane Central Register of Controlled Trials, PUBMED, EMBASE, and other databases were searched, and outcomes measured by the Total Unified Parkinson's Disease Rating Scale (UPDRS) and the Schwab & England Scale were analyzed. RESULTS: Five randomized controlled trials (RCTs) were selected, and 1339 participants were included in the analysis. There were no significant differences between the control and treatment groups in the total, mental, activities of daily living (ADL), or motor UPDRS scores, but an improvement in Schwab & England Scale scores was observed. CONCLUSIONS: Creatine has no observed benefit in PD patients, although more correlated studies are still needed.

Key Findings

Five randomized controlled trials (RCTs) were selected, and 1339 participants were included in the analysis. There were no significant differences between the control and treatment groups in the total, mental, activities of daily living (ADL), or motor UPDRS scores, but an improvement in Schwab & England Scale scores was observed.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 1339
Age Range See abstract
Condition See abstract

MeSH Terms

  • Activities of Daily Living
  • Creatine
  • Humans
  • Parkinson Disease
  • Randomized Controlled Trials as Topic
  • Treatment Outcome

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis
  • Vertical: creatine-neurological

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09