Vitamin D in cancer chemoprevention

source extracted confidence: high 2026-04-09
#animals #antineoplastic-agents #breast-neoplasms #chemoprevention #clinical-trials-as-topic

Vitamin D in cancer chemoprevention

Giammanco et al., 2015 | Pharm Biol | Systematic Review

Citation

Giammanco Marco, Di Majo Danila, ... Leto Gaetano. Vitamin D in cancer chemoprevention. Pharm Biol. 2015;53(10):1399-434. doi:10.3109/13880209.2014.988274

Abstract

CONTEXT: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo. OBJECTIVE: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy. METHODS: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar. RESULTS AND CONCLUSION: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents.

Key Findings

Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents.

Outcomes Measured

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Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Animals
  • Antineoplastic Agents
  • Breast Neoplasms
  • Chemoprevention
  • Clinical Trials as Topic
  • Colorectal Neoplasms
  • Female
  • Growth Inhibitors
  • Humans
  • Immunologic Factors
  • Male
  • Neoplasms
  • Prostatic Neoplasms
  • Vitamin D

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: vitamin-d-cancer

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09