Glucose-insulin-potassium therapy in patients with acute coronary syndrome: a meta-analysis of randomized controlled trials

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#acute-coronary-syndrome #cardioplegic-solutions #chi-square-distribution #drug-administration-schedule #glucose

Glucose-insulin-potassium therapy in patients with acute coronary syndrome: a meta-analysis of randomized controlled trials

Jin et al., 2014 | BMC Cardiovasc Disord | Meta Analysis

Citation

Jin Pei-Yin, Zhang Hai-San, ... Han Qin-Fu. Glucose-insulin-potassium therapy in patients with acute coronary syndrome: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2014-Nov-25;14:169. doi:10.1186/1471-2261-14-169

Abstract

BACKGROUND: Glucose-insulin-potassium (GIK) has been advocated in the setting of acute coronary syndrome (ACS) to reduce ischemia-related arrhythmias and myocardial injury. We conducted a meta-analysis of randomized controlled trials (RCTs) to assess whether the use of GIK infusions >3 or <3 hours after the onset of symptoms reduce mortality or cardiac arrest. METHODS: Electronic databases (Medline, EMBASE, and Cochrane Central Register of Controlled Trials) and references of retrieved articles were searched for RCTs evaluating the effect of GIK infusions, <3 hours or >3 hours after the onset of symptoms, on mortality and/or cardiac arrest. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for each outcome. RESULTS: Nine trials were identified and eligible for review. The summary OR for in-hospital mortality was 1.01 (95% CI 0.94 to 1.09), based on 2,542 deaths among 27,294 patients. The subgroup analysis according to the study enrollment time (within 3 hours [OR, 0.77, 95% CI 0.50-1.16], vs. >3 hours [OR, 0.90; 95% CI, 0.67-1.21]) did not reveal any difference in mortality. CONCLUSIONS: Administration of GIK in ACS patients does not significantly reduce mortality whether or not GIK administration >3 or <3 hours after the onset of symptoms.

Key Findings

Nine trials were identified and eligible for review. The summary OR for in-hospital mortality was 1.01 (95% CI 0.94 to 1.09), based on 2,542 deaths among 27,294 patients. The subgroup analysis according to the study enrollment time (within 3 hours [OR, 0.77, 95% CI 0.50-1.16], vs. >3 hours [OR, 0.90; 95% CI, 0.67-1.21]) did not reveal any difference in mortality.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 27294
Age Range See abstract
Condition See abstract

MeSH Terms

  • Acute Coronary Syndrome
  • Cardioplegic Solutions
  • Chi-Square Distribution
  • Drug Administration Schedule
  • Glucose
  • Heart Arrest
  • Hospital Mortality
  • Humans
  • Infusions, Parenteral
  • Insulin
  • Odds Ratio
  • Potassium
  • Randomized Controlled Trials as Topic
  • Risk Factors
  • Time Factors
  • Time-to-Treatment
  • Treatment Outcome

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: potassium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09