Methods of assessment of selenium status in humans: a systematic review

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#biomarkers #clinical-trials-as-topic #dietary-supplements #glutathione-peroxidase #humans

Methods of assessment of selenium status in humans: a systematic review

Ashton et al., 2009 | Am J Clin Nutr | Systematic Review

Citation

Ashton Kate, Hooper Lee, ... Fairweather-Tait Susan J. Methods of assessment of selenium status in humans: a systematic review. Am J Clin Nutr. 2009-Jun;89(6):2025S-2039S. doi:10.3945/ajcn.2009.27230F

Abstract

BACKGROUND: To understand the effect of selenium intake on health, it is important to identify sensitive and population-specific biomarkers of selenium status. OBJECTIVE: The objective of this systematic review was to assess the usefulness of biomarkers of selenium status in humans. DESIGN: The methods included a structured search strategy on Ovid MEDLINE, EMBASE (Ovid), and Cochrane databases; formal inclusion and exclusion criteria; data extraction into an Access database; validity assessment; and meta-analysis. RESULTS: The data from 18 selenium supplementation studies (of which 9 were randomized controlled trials and 1 was considered to be at low risk of bias) indicate that plasma, erythrocyte, and whole-blood selenium, plasma selenoprotein P, and plasma, platelet, and whole-blood glutathione peroxidase activity respond to changes in selenium intake. Although there is a substantial body of data for plasma selenium, more large, high-quality, randomized controlled trials are needed for this biomarker, as well as for the other biomarkers, to explore the reasons for heterogeneity in response to selenium supplementation. There was insufficient evidence to assess the usefulness of other potential biomarkers of selenium status, including urinary selenium, plasma triiodothyroxine:thyroxine ratio, plasma thyroxine, plasma total homocysteine, hair and toenail selenium, erythrocyte, and muscle glutathione peroxidase activity. CONCLUSIONS: For all potentially useful biomarkers, more information is needed to evaluate their strengths and limitations in different population groups, including the effects of varying intakes, the duration of intervention, baseline selenium status, and possible confounding effects of genotype.

Key Findings

The data from 18 selenium supplementation studies (of which 9 were randomized controlled trials and 1 was considered to be at low risk of bias) indicate that plasma, erythrocyte, and whole-blood selenium, plasma selenoprotein P, and plasma, platelet, and whole-blood glutathione peroxidase activity respond to changes in selenium intake. Although there is a substantial body of data for plasma selenium, more large, high-quality, randomized controlled trials are needed for this biomarker, as well as

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Biomarkers
  • Clinical Trials as Topic
  • Dietary Supplements
  • Glutathione Peroxidase
  • Humans
  • Methods
  • Nutrition Assessment
  • Nutritional Status
  • Selenium
  • Selenoproteins
  • Trace Elements

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: selenium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09