[Advances in the study of berberine and its derivatives]

source extracted confidence: high 2026-04-09
#alzheimer-disease #animals #anti-arrhythmia-agents #antineoplastic-agents-phytogenic #apoptosis

[Advances in the study of berberine and its derivatives]

Li et al., 2008 | Yao Xue Xue Bao | Systematic Review

Citation

Li Bo, Zhu Wei-Liang, Chen Kai-Xian. [Advances in the study of berberine and its derivatives]. Yao Xue Xue Bao. 2008-Aug;43(8):773-87

Abstract

Berberine is a isoquinoline alkaloid extracted from Chinese herbs such as Coptidis rhizome. In the past decade, there are more than 2 000 published papers studying the clinical application, pharmacodynamic mechanism and structure-activity relationship (SAR) of berberine and its derivatives, for treating tumor, diabetes, cardiavascellum disease, hyperlipemia, inflammation, bacterium and virus infection, cerebral ischemia trauma, mental disease, Alzheimer disease, osteoporosis, and so on. These results demonstrate that berberine has wide physiologic function and has great potential for structural modification as new drug lead. However, there is no systematic review about the study of berberine and its derivatives up to now. This paper is a systematic review of the research advances of berberine and its derevatives in clinical application, pharmacodynamic mechanisms, molecular pharmacology, absorption and metabolism, and SAR studies. The current review would provide some useful information for further study on structural modification of berberine for discovering new drug leads based on its pharmacodynamic mechanisms.

Key Findings

The current review would provide some useful information for further study on structural modification of berberine for discovering new drug leads based on its pharmacodynamic mechanisms.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition diabetes

MeSH Terms

  • Alzheimer Disease
  • Animals
  • Anti-Arrhythmia Agents
  • Antineoplastic Agents, Phytogenic
  • Apoptosis
  • Berberine
  • Cardiovascular Diseases
  • Cell Line, Tumor
  • Diabetes Mellitus
  • Humans
  • Hypoglycemic Agents
  • Structure-Activity Relationship

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: berberine

Provenance

  • PMID: 18956768
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09