Meta-analysis of intraoperative povidone-iodine application to prevent surgical-site infection

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#anti-infective-agents-local #humans #intraoperative-care #povidone-iodine #randomized-controlled-trials-as-topic

Meta-analysis of intraoperative povidone-iodine application to prevent surgical-site infection

Fournel et al., 2010 | Br J Surg | Meta Analysis

Citation

Fournel I, Tiv M, ... Aho Glélé L S. Meta-analysis of intraoperative povidone-iodine application to prevent surgical-site infection. Br J Surg. 2010-Nov;97(11):1603-13. doi:10.1002/bjs.7212

Abstract

BACKGROUND: The effectiveness of intraoperative povidone-iodine (PVI) application in the reduction of surgical-site infection (SSI) remains controversial. This meta-analysis was performed to assess the effect of intraoperative PVI application compared with no antiseptic solution (saline or nothing) on the SSI rate. METHODS: The meta-analysis included randomized controlled trials that compared intraoperative PVI lavage with no PVI in patients undergoing surgery with SSI as the primary outcome. A fixed-effects or random-effects model was used as appropriate, and heterogeneity was assessed by the Cochran Q and the I(2) value. RESULTS: Twenty-four randomized controlled trials totalling 5004 patients (2465 patients with PVI and 2539 patients without) were included: 15 in the main analysis and nine in the sensitivity analysis. The rate of SSI was 8.0 per cent in the PVI group and 13.4 per cent in the control group. Intraoperative PVI application significantly decreased the SSI rate (relative risk 0.58, 95 per cent confidence interval 0.40 to 0.83; P = 0.003) and consistent results were observed in subgroup analyses according to the method of PVI administration, its timing and the type of surgery. CONCLUSION: The meta-analysis results suggested that the use of intraoperative PVI reduced rates of SSI.

Key Findings

Twenty-four randomized controlled trials totalling 5004 patients (2465 patients with PVI and 2539 patients without) were included: 15 in the main analysis and nine in the sensitivity analysis. The rate of SSI was 8.0 per cent in the PVI group and 13.4 per cent in the control group. Intraoperative PVI application significantly decreased the SSI rate (relative risk 0.58, 95 per cent confidence interval 0.40 to 0.83; P = 0.003) and consistent results were observed in subgroup analyses according to

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population pvi and 2539 patients
Sample Size 5004
Age Range See abstract
Condition See abstract

MeSH Terms

  • Anti-Infective Agents, Local
  • Humans
  • Intraoperative Care
  • Povidone-Iodine
  • Randomized Controlled Trials as Topic
  • Surgical Wound Infection
  • Treatment Outcome

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: iodine

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09