⚠️ Mechanism
High-dose vitamin E may inhibit vitamin K-dependent carboxylation.
📋 Effect
Possible increased anticoagulant effect at doses >400 IU/day
💊 Management
Avoid vitamin E >400 IU/day with warfarin. Monitor INR.
Plain Language Summary
Taking high doses of Vitamin E (more than 400 IU per day) with warfarin can be risky. These high amounts may increase the blood-thinning effect of the medication, which could lead to an increased risk of bleeding.
Source
Corrigan JJ Jr. Am J Clin Nutr 1991
Supporting Research
Exercise for intermittent claudication
Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis
Effect of vitamin E supplementation in rheumatoid arthritis: a systematic review and meta-analysis
Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement.
Antioxidants for chronic kidney disease
Exercise for intermittent claudication
Treatment for cramps in amyotrophic lateral sclerosis/motor neuron disease
Association of blood antioxidants and vitamins with risk of age-related cataract: a meta-analysis of observational studies
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.