⚠️ Mechanism
High-dose vitamin C may protect tumor cells from oxidative damage caused by some chemotherapies, or may interfere with pro-oxidant mechanisms of certain agents.
📋 Effect
Possible reduction in chemotherapy efficacy
💊 Management
Avoid high-dose vitamin C (>500mg/day) during chemotherapy without oncologist approval.
Plain Language Summary
Taking high doses of Vitamin C during chemotherapy may be risky because it could interfere with the treatment's effectiveness. High amounts of this vitamin might protect tumor cells from the damage the chemotherapy is intended to cause.
Source
Lawenda BD et al. J Natl Cancer Inst 2008
Supporting Research
Vitamin E supplementation in pregnancy
Nutritional interventions for preventing and treating pressure ulcers
Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Vitamin C in Critically Ill Patients: An Updated Systematic Review and Meta-Analysis
Reminder packaging for improving adherence to self-administered long-term medications
Nutritional interventions for preventing and treating pressure ulcers
Interventions to reduce haemorrhage during myomectomy for fibroids
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.