⚠️ Mechanism
Valerian has sedative properties that may add to CNS depressant effects.
📋 Effect
Excessive sedation; impaired alertness
💊 Management
Avoid combining with prescription sedatives without medical supervision.
Plain Language Summary
This combination can be dangerous because Valerian can increase the sleepiness caused by sedatives. This may lead to excessive drowsiness and difficulty staying alert.
Source
Carr AC et al. Sleep Med Rev 2015
Supporting Research
Non-pharmacological interventions for sleep promotion in the intensive care unit
Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review
Herbal medicine for insomnia: A systematic review and meta-analysis
Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review
Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep
Herbal medicines in children with attention deficit hyperactivity disorder (ADHD): A systematic review
Relationship between concentrations of microbiological agents in the air of agricultural settings and occurrence of work-related symptoms in exposed persons
A systematic review of insomnia and complementary medicine
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.