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Valerian × Oral Contraceptives

MODERATE INTERACTION

⚠️ Mechanism

Valerian is a weak inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.

📋 Effect

Increased plasma levels of ethinylestradiol (oral-contraceptives), potentially leading to toxicity or enhanced adverse effects.

💊 Management

Monitor for increased adverse effects of ethinylestradiol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.

Plain Language Summary

This combination carries a moderate risk because Valerian can slow down how your body processes the hormones in oral contraceptives. This may cause higher levels of the medication to build up in your system, which could increase the risk of side effects.

Source

Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)

Supporting Research

Non-pharmacological interventions for sleep promotion in the intensive care unit PMID:26439374 DOI:10.1002/14651858.CD008808.pub2 2015
Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review PMID:33495257 DOI:10.1136/bmjopen-2020-043363 2021
Herbal medicine for insomnia: A systematic review and meta-analysis PMID:25644982 DOI:10.1016/j.smrv.2014.12.003 2015
Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review PMID:39064758 DOI:10.3390/nu16142315 2024
Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep PMID:33561990 DOI:10.3390/nu13020530 2021
Herbal medicines in children with attention deficit hyperactivity disorder (ADHD): A systematic review PMID:28137522 DOI:10.1016/j.ctim.2016.11.004 2017
Relationship between concentrations of microbiological agents in the air of agricultural settings and occurrence of work-related symptoms in exposed persons PMID:26403118 DOI:10.5604/12321966.1167717 2015
A systematic review of insomnia and complementary medicine PMID:20965131 DOI:10.1016/j.smrv.2010.04.001 2011
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.