St Johns Wort × Verapamil Interaction — Severity, Mechanism & Management

⚠️ Mechanism

St. John's wort induces CYP3A4, increasing verapamil metabolism.

📋 Effect

Reduced verapamil levels; loss of blood pressure/heart rate control

💊 Management

Monitor blood pressure and heart rate. May need dose adjustment.

Plain Language Summary

This combination requires caution because St. John's Wort can cause your body to break down Verapamil more quickly. This may lead to lower levels of the medication in your system, potentially making it less effective at controlling your blood pressure and heart rate.

Source

Dresser GK et al. Clin Pharmacol Ther 2003

Supporting Research

The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial PMID:31331546 DOI:10.1016/j.ctim.2019.05.028 2019

Hypericum extract LI 160 and fluoxetine in mild to moderate depression: a randomized, placebo-controlled multi-center study in outpatients PMID:15538592 2005

[Hypericum perforatum extract in treatment of mild to moderate depression. Clinical and pharmacological aspects] PMID:12212522 2002

Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression PMID:12008860 2002

Efficacy of continuation treatment with hypericum perforatum in depression PMID:12019675 2002

Predicting stable treatment response in patients with major depression treated with hypericum extract WS 5570/5572 PMID:16189745 2005

Adverse Event Profile: St Johns Wort 0

Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.