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St Johns Wort × Doxepin (topical)

CRITICAL INTERACTION

⚠️ Mechanism

Interaction identified from DDInter 2.0 database. Specific drugs: Doxepin (topical)

📋 Effect

See mechanism description

💊 Management

Consult healthcare provider before combining.

Plain Language Summary

This combination is considered dangerous because it involves a critical interaction. The data recommends consulting a healthcare provider before using St. John's Wort and topical Doxepin together.

Source

DDInter 2.0 (ddinter.scbdd.com)

Supporting Research

The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial PMID:31331546 DOI:10.1016/j.ctim.2019.05.028 2019
Hypericum extract LI 160 and fluoxetine in mild to moderate depression: a randomized, placebo-controlled multi-center study in outpatients PMID:15538592 2005
[Hypericum perforatum extract in treatment of mild to moderate depression. Clinical and pharmacological aspects] PMID:12212522 2002
Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression PMID:12008860 2002
Efficacy of continuation treatment with hypericum perforatum in depression PMID:12019675 2002
Predicting stable treatment response in patients with major depression treated with hypericum extract WS 5570/5572 PMID:16189745 2005
Adverse Event Profile: St Johns Wort 0
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.