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Probiotics × Antibiotics

MINOR Well-Established Evidence

Mechanism

Probiotics may reduce antibiotic-associated diarrhea. However, antibiotics may kill probiotic organisms.

Effect

Probiotics may reduce antibiotic side effects; timing matters

Management

Take probiotics 2+ hours after antibiotics. Continue for duration of antibiotic course + 1 week.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This interaction is considered minor and generally safe. While antibiotics can kill the beneficial bacteria in probiotics, taking probiotics at a separate time from your antibiotic may help reduce side effects like diarrhea.

Source

Hempel S et al. JAMA 2012 Cochrane review

Research

Supporting Research

Probiotics for maintenance of remission in ulcerative colitis
PMID:32128794 DOI 2020
Probiotics for induction of remission in ulcerative colitis
PMID:32128795 DOI 2020
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
PMID:29257353 DOI 2017
Effect of chicory-derived inulin-type fructans on abundance of Bifidobacterium and on bowel function: a systematic review with meta-analyses
PMID:35833477 DOI 2023
Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis
PMID:29757343 DOI 2018
Probiotics for preventing gestational diabetes
PMID:33870484 DOI 2021
Probiotics for treating acute infectious diarrhoea
PMID:21069673 DOI 2010
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
PMID:23728658 DOI 2013
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.