⚠️ Mechanism
Probiotics may reduce antibiotic-associated diarrhea. However, antibiotics may kill probiotic organisms.
📋 Effect
Probiotics may reduce antibiotic side effects; timing matters
💊 Management
Take probiotics 2+ hours after antibiotics. Continue for duration of antibiotic course + 1 week.
Plain Language Summary
This interaction is considered minor and generally safe. While antibiotics can kill the beneficial bacteria in probiotics, taking probiotics at a separate time from your antibiotic may help reduce side effects like diarrhea.
Source
Hempel S et al. JAMA 2012 Cochrane review
Supporting Research
Probiotics for maintenance of remission in ulcerative colitis
Probiotics for induction of remission in ulcerative colitis
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
Effect of chicory-derived inulin-type fructans on abundance of Bifidobacterium and on bowel function: a systematic review with meta-analyses
Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis
Probiotics for preventing gestational diabetes
Probiotics for treating acute infectious diarrhoea
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.