⚠️ Mechanism
Niacin + statins synergistically increase myopathy risk, especially at niacin doses >1g/day.
📋 Effect
Increased myopathy risk; possible rhabdomyolysis
💊 Management
Monitor CK levels. Limit niacin to <1g/day with statins.
Plain Language Summary
This combination can be risky because it increases the chance of experiencing muscle damage. Taking niacin and statins together may lead to muscle pain or more serious muscle breakdown, especially at higher doses of niacin.
Source
AIM-HIGH Trial; HPS2-THRIVE Collaborative Group
Supporting Research
Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Antidepressants for smoking cessation
Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Bupropion for attention deficit hyperactivity disorder (ADHD) in adults
Lipid-lowering agents for nephrotic syndrome
Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.