Melatonin × Warfarin
MINOR
Possible Evidence
Mechanism
Melatonin may affect CYP2C9 activity, potentially altering warfarin metabolism.
Effect
Possible minor INR changes
Management
Monitor INR if starting melatonin. Interaction is of minor clinical concern.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyThis combination is considered to have a minor risk. Melatonin may slightly change how your body breaks down warfarin, which could affect your blood's ability to clot. If you start taking melatonin, your doctor may need to monitor your blood clotting levels more closely.
Source
Hermida RC et al. Chronobiol Int 2002
Research
Supporting Research
Interventions for preventing delirium in hospitalised non-ICU patients
Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Pharmacological interventions for prevention of weight gain in people with schizophrenia
Prevention of depression in adults with long-term physical conditions
Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Second-generation antidepressants for preventing seasonal affective disorder in adults
Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.