Melatonin × Sedatives
MODERATE
Probable Evidence
Mechanism
Melatonin has sedative properties that may add to CNS depressant effects.
Effect
Excessive sedation; impaired alertness
Management
Use caution with benzodiazepines, barbiturates, and other sedatives. Start with low melatonin dose.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyThis combination can be risky because it may cause excessive sleepiness. Melatonin can increase the effects of sedatives, potentially making you feel very drowsy or less alert.
Source
Andrade C et al. J Clin Psychiatry 2004
Research
Supporting Research
Interventions for preventing delirium in hospitalised non-ICU patients
Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
Pharmacological interventions for prevention of weight gain in people with schizophrenia
Prevention of depression in adults with long-term physical conditions
Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Second-generation antidepressants for preventing seasonal affective disorder in adults
Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.