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Magnesium × Tetracyclines

MODERATE Well-Established Evidence

Mechanism

Magnesium chelates tetracycline antibiotics, reducing absorption.

Effect

Reduced tetracycline absorption and efficacy

Management

Separate doses by at least 2 hours before or 4 hours after tetracycline.

Plain Language Summary

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This combination can be problematic because magnesium can prevent your body from absorbing tetracycline antibiotics effectively. Magnesium binds to the medication, which may reduce its effectiveness. The data suggests separating these doses by at least two hours before or four hours after the antibiotic.

Source

Neuvonen PJ. Drugs 1976

Research

Supporting Research

The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
PMID:33419615 DOI 2021
Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery
PMID:23440790 DOI 2013
Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies
PMID:36986033 DOI 2023
A meta-analysis of methane-mitigation potential of feed additives evaluated in vitro
PMID:38353472 DOI 2024
Dietary Approaches to Stop Hypertension (DASH) for the primary and secondary prevention of cardiovascular diseases
PMID:40326569 DOI 2025
Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies
PMID:23719551 DOI 2013
Inhaled magnesium sulfate in the treatment of acute asthma
PMID:29182799 DOI 2017
Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users
PMID:29543325 DOI 2018
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Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.