⚠️ Mechanism
Magnesium chelates tetracycline antibiotics, reducing absorption.
📋 Effect
Reduced tetracycline absorption and efficacy
💊 Management
Separate doses by at least 2 hours before or 4 hours after tetracycline.
Plain Language Summary
This combination can be problematic because magnesium can prevent your body from absorbing tetracycline antibiotics effectively. Magnesium binds to the medication, which may reduce its effectiveness. The data suggests separating these doses by at least two hours before or four hours after the antibiotic.
Source
Neuvonen PJ. Drugs 1976
Supporting Research
The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery
Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies
A meta-analysis of methane-mitigation potential of feed additives evaluated in vitro
Dietary Approaches to Stop Hypertension (DASH) for the primary and secondary prevention of cardiovascular diseases
Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies
Inhaled magnesium sulfate in the treatment of acute asthma
Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.