⚠️ Mechanism
Magnesium may reduce levothyroxine absorption, similar to calcium.
📋 Effect
Reduced levothyroxine absorption; hypothyroid symptoms
💊 Management
Separate doses by at least 4 hours.
Plain Language Summary
This combination requires caution because magnesium can prevent your body from absorbing levothyroxine properly. This may lead to symptoms of an underactive thyroid if the doses are taken too close together.
Source
Singh N et al. JAMA 2000 (extrapolated from calcium data)
Supporting Research
The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery
Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies
A meta-analysis of methane-mitigation potential of feed additives evaluated in vitro
Dietary Approaches to Stop Hypertension (DASH) for the primary and secondary prevention of cardiovascular diseases
Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies
Inhaled magnesium sulfate in the treatment of acute asthma
Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.