Magnesium × Fluoroquinolones
MODERATE
Well-Established Evidence
Mechanism
Magnesium chelates fluoroquinolone antibiotics, reducing absorption.
Effect
Reduced antibiotic absorption and efficacy
Management
Separate doses by at least 2 hours before or 6 hours after antibiotic.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyThis combination can be problematic because magnesium can prevent your body from absorbing fluoroquinolone antibiotics properly. This interaction may result in the antibiotic not being as effective at treating your infection.
Source
FDA fluoroquinolone labeling
Research
Supporting Research
The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery
Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies
A meta-analysis of methane-mitigation potential of feed additives evaluated in vitro
Dietary Approaches to Stop Hypertension (DASH) for the primary and secondary prevention of cardiovascular diseases
Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies
Inhaled magnesium sulfate in the treatment of acute asthma
Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.