Magnesium × Bisphosphonates
MODERATE
Well-Established Evidence
Mechanism
Magnesium interferes with bisphosphonate absorption.
Effect
Reduced bisphosphonate absorption
Management
Take bisphosphonate at least 30 minutes before magnesium.
Plain Language Summary
AI-generated · Qwen 3.6 · grounded in 2 sources · methodologyThis combination can cause a moderate interaction that may affect how well your medication works. Magnesium can interfere with the absorption of bisphosphonates, potentially reducing the amount of medicine your body receives.
Source
FDA alendronate labeling
Research
Supporting Research
The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery
Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies
A meta-analysis of methane-mitigation potential of feed additives evaluated in vitro
Dietary Approaches to Stop Hypertension (DASH) for the primary and secondary prevention of cardiovascular diseases
Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies
Inhaled magnesium sulfate in the treatment of acute asthma
Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications.