⚠️ Mechanism
Licorice is a moderate inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of simvastatin (statins), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of simvastatin. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination may be moderately unsafe because licorice can prevent your body from breaking down statins properly. This can cause the medication to build up in your bloodstream, potentially increasing your risk of side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Effective licorice gargle juice for aphthous ulcer pain relief: A randomized double-blind placebo-controlled trial
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.