⚠️ Mechanism
Licorice is a moderate inhibitor of CYP3A4, which decreases metabolism of CYP3A4 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of omeprazole (ppis), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of omeprazole. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination carries a moderate risk because licorice can slow down how your body processes certain acid-reducing medications. This can cause the medication levels to rise in your bloodstream, potentially increasing the risk of side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Effective licorice gargle juice for aphthous ulcer pain relief: A randomized double-blind placebo-controlled trial
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.