⚠️ Mechanism
Licorice is a weak inhibitor of CYP2C19, which decreases metabolism of CYP2C19 substrates, potentially increasing their plasma concentrations and risk of adverse effects.
📋 Effect
Increased plasma levels of propranolol (beta-blockers), potentially leading to toxicity or enhanced adverse effects.
💊 Management
Monitor for increased adverse effects of propranolol. Dose reduction may be necessary. Consider alternative supplement or consult healthcare provider.
Plain Language Summary
This combination carries a moderate risk because licorice can slow down how your body processes beta-blockers. This may cause the medication to build up in your system, potentially leading to more side effects.
Source
Flockhart CYP450 Table (drug-interactions.medicine.iu.edu)
Supporting Research
Effective licorice gargle juice for aphthous ulcer pain relief: A randomized double-blind placebo-controlled trial
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.